COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

摘要

The invention provides a novel class of compounds of Formula (see formula I) and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, FIt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-ll, Rskl, SGK, TrkA, TrkB and TrkC kinases.