发明名称 |
Nontypeable Haemophilus Influenzae Virulence Factors |
摘要 |
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.
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申请公布号 |
US2011223174(A1) |
申请公布日期 |
2011.09.15 |
申请号 |
US201113042150 |
申请日期 |
2011.03.07 |
申请人 |
NATIONWIDE CHILDREN'S HOSPITAL, INC. |
发明人 |
BAKALETZ LAUREN O.;MUNSON, JR. ROBERT S. |
分类号 |
A61K39/395;A61K31/713;A61K38/16;A61K39/00;A61K39/102;A61P27/16;A61P31/04;A61P31/16;C07H21/04;C07K14/285;C07K16/12;C12N15/31;C12Q1/68;G01N33/569 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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