发明名称 |
METHOD OF TREATMENT OF VASCULAR COMPLICATIONS |
摘要 |
The present invention provides methods for the prevention or treatment of one or more vascular complication(s) in a subject at risk of developing diabetes mellitus, impaired glucose tolerance and/or hyperglycaemia or a subject suffering from diabetes mellitus, impaired glucose tolerance and/or hyperglycaemia, wherein an amount of a composition effective to inhibit, repress, delay or otherwise reduce expression and/or activity and/or level of TXNIP and/or an amount of a composition effective to induce, enhance or otherwise increase expression and/or activity and/or level of TRX is/are administered to a subject in need thereof. The present invention also provides methods for identifying and isolating modulators of TXNIP expression and/or activity and/or level and/or TRX expression and/or activity and/or level for use in such therapeutic and prophylactic methods. |
申请公布号 |
EP2304049(A4) |
申请公布日期 |
2011.09.14 |
申请号 |
EP20090768642 |
申请日期 |
2009.06.29 |
申请人 |
THE HEART RESEARCH INSTITUTE LIMITED |
发明人 |
NG, MARTIN KEAN CHONG;DUNN, LOUISE LORRAINE;BUCKLE, ANDREW |
分类号 |
C12Q1/26;A61K38/00;A61K39/00;A61K48/00;A61P3/10;A61P9/00;G01N33/53 |
主分类号 |
C12Q1/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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