发明名称 |
ENPP1 (PC-1) gene haplotype associated with the risk of obesity and type 2 diabetes and their applications |
摘要 |
The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype comprising three specific SNPs in a DNA or RNA sample of this subject and/or an elevated serum ENPP1 protein concentration. The present invention also relates to a kit and to an isolated nucleic sequence, vector or recombinant cell comprises said ENPP1 gene haplotype. The invention further comprises a method for selecting a compound for the treatment or the prevention of obesity or pathology related to obesity and a method for determining the efficacy of a drug to reduce the risk of obesity or pathology related to obesity in a patient. |
申请公布号 |
US8017324(B1) |
申请公布日期 |
2011.09.13 |
申请号 |
US20060917586 |
申请日期 |
2006.06.15 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE DE DROIT DE LA LA SANTE DE LILLE 2 |
发明人 |
FROGUEL PHILIPPE;MEYRE DAVID;DINA CHRISTIAN;BOUTIN PHILIPPE |
分类号 |
C12Q1/68;C07H21/02;C07H21/04;C12P19/34;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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