DIMETHYL 4-PHENYLETHYLAMINO-2-(4-METHOXYPHENYL)-6-HYDROXY-6-METHYL-3-CYCLOHEXENE-1,3-DICARBOXYLATE EXHIBITING ANTI-INFLAMMATORY ACTION

摘要

FIELD: chemistry. ^ SUBSTANCE: compound has formula (I): ^ ^ The compound is obtained through arylamination of 2-(4-methoxyphenyl)-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxylate with phenylethylamine in the presence of acetic acid in ethanol. The compound is a yellow crystalline substance with Tm=130C, which is soluble in dimethyl sulphoxide (DMSO) and dimethyl formamide (DMFA) but not soluble in water. LD50 during intraperitoneal administration to white mice was greater than 10000 mg/kg. ^ EFFECT: high anti-inflammatory action of the compound. ^ 1 tbl