FIBRINOGEN PREPARATIONS ENRICHED IN FIBRINOGEN WITH AN EXTENDED ALPHA CHAIN

摘要

The present invention relates to fibrinogen preparations enriched in a-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of a-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by a-extended fibrinogen are improved. In addition, plasmin-mediated degradation of a-extended fibrinogen is reduced as compared to plasma derived fibrinogen.