MATERIALS AND METHODS FOR MRI CONTRAST AGENTS AND DRUG DELIVERY

摘要

A MRI contrast agent used for medical imaging is provided as a class of non-gadolinium and non-iron oxide based materials that can be used as T1-weighted and/or T2-weighted MRI contrast agents for cellular imaging in clinical diagnosis and biomedical research applications. The contrast agent is a compound created from Prussian blue materials that is non-toxic, and can be internalized by cells through endocytosis. The Prussian blue materials may also be used for drug delivery applications. The Prussian blue materials may be administered orally to a subject in either medical imaging or drug delivery applications or dual modality MRI-Fluorescence imaging agent.