| 摘要 |
PROBLEM TO BE SOLVED: To develop a compound which is well absorbed orally, exhibits durability of good blood level and has potent calpain inhibitory activity. SOLUTION: The compound represented by general formula (I) (wherein R<SP>1</SP>is a lower alkyl substituted by a lower alkoxy or a heterocyclic group, or a heterocyclic group; R<SP>2</SP>is a lower alkyl optionally substituted by a phenyl; and R<SP>3</SP>is a lower alkyl optionally substituted by a halogen, a lower alkoxy or a phenyl, or a fused polycyclic hydrocarbon group), and having a calpain inhibitory activity. COPYRIGHT: (C)2006,JPO&NCIPI |
