发明名称 |
Tagged ligands for enrichment of rare analytes from a mixed sample |
摘要 |
Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular marker of the rare cells and the affinity tag can be selectively captured by a capture moiety, wherein the affinity tags do not comprise a magnetic particle; and flowing the sample through a microfluidic device comprising the capture moiety to selectively retain ATL-bound cells. Methods for enriching circulating tumor cells, and devices for enriching specific cells from cellular samples are also disclosed.
|
申请公布号 |
US8008032(B2) |
申请公布日期 |
2011.08.30 |
申请号 |
US20080037077 |
申请日期 |
2008.02.25 |
申请人 |
CELLECTIVE DX CORPORATION |
发明人 |
FORSYTH ALLYN;BARNES HELEN |
分类号 |
G01N33/574;B01L3/00;G01N1/18;G01N37/00 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|