发明名称 |
Adenovirus 36 E4 orf 1 gene and protein and their uses |
摘要 |
Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.
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申请公布号 |
US8008436(B2) |
申请公布日期 |
2011.08.30 |
申请号 |
US20060095441 |
申请日期 |
2006.11.30 |
申请人 |
WAYNE STATE UNIVERISTY;BOARD OF SUP. OF LSU AND AGR. & MECHANICAL COLLEGE |
发明人 |
DHURANDHAR NIKHIL V.;HOLLAND THOMAS C.;WANG ZHONG Q. |
分类号 |
C07K14/075 |
主分类号 |
C07K14/075 |
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地址 |
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