发明名称 |
Vaccine composition comprising interleukin-15 (IL-15) |
摘要 |
Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host. IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide. Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.
|
申请公布号 |
US8007776(B2) |
申请公布日期 |
2011.08.30 |
申请号 |
US20050529923 |
申请日期 |
2005.08.29 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
SAVIO ALICIA SANTOS;RODRIGUEZ RICARDO SILVA;DIAZ YANELIS MORERA;RODRIQUEZ ALFONSO ARMANDO ALEXEI;MARTINEZ CASTILLO JOSE RAFAEL;PEREZ HAYDEE GERONIMO;SORIA ALEJANDRO MORO;PEREA RODRIGUEZ SILVIO ERNESTO |
分类号 |
A61K38/20;A61K39/00 |
主分类号 |
A61K38/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|