Quinazolines useful as modulators of voltage gated ion channels

摘要

Disclosed are substituted quinazoline compound of formula (IA) or formula (IB), wherein the variables are as defined in the specification, which have the activity as inhibitors of voltage-gate sodium channels, and are suitable for use in the treatment of disease, condition, or disorder that is implicated in the activation or hyperactivity of voltage-gated sodium channels, wherein the disease, condition, or disorder is selected from acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy or epilepsy conditions, neurodegenerative disorders, psychiatric disorders such as anxiety and depression, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, postherpetic neuralgia, diabetic neuropathy, radicular pain, sciatica, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, or cancer pain.