ALZHEIMER'S DISEASE-SPECIFIC ALTERATIONS OF PROTEIN KINASE C EPSILON (PKC-EPSILON) PROTEIN LEVELS
摘要
<p>The present invention relates to methods of diagnosing Alzheimer's Disease in a human patient by detecting alterations in the ratio of PKC epsilon protein levels in a human patient compared with PKC epsilon levels in a control subject. The Alzheimer's disease- specific molecular biomarkers disclosed herein are useful for the diagnosis of Alzheimer's disease and for screening methods for the identification of compounds for treating or preventing Alzheimer's disease. The present invention also provides methods for elevating PKC epsilon protein levels comprising the steps of contacting one or more human cells with an amount of a PKC activator effective to elevate PKC epsilon levels compared to an uncontacted human cell.</p>
申请公布号
WO2011102907(A1)
申请公布日期
2011.08.25
申请号
WO2011US00315
申请日期
2011.02.22
申请人
BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE;KHAN, TAPAN, K.;ALKON, DANIEL, L.