Production of galactosylated glycoproteins in lower eukaryotes
摘要
PRODUCTION OF GALA CTOSYLA TED GLYCOPROTEINS IN LOWER EUKARYOTES Abstract The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a P-galactose residue and essentially 10 lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.
申请公布号
AU2011205185(A1)
申请公布日期
2011.08.25
申请号
AU20110205185
申请日期
2011.08.05
申请人
GLYCOFI, INC.
发明人
CHOI, BYUNG-KWON;NETT, JUERGEN;BOBROWICZ, PIOTR;GERNGROSS, TILLMAN;TILLMAN, WILDT;WILDT, STEFAN;HAMILTON, STEPHEN;DAVIDSON, ROBERT