摘要 |
<p>The invention is directed to novel pyrrolopyrimidine compounds of formula (I) wherein R1, R2Y, R4, R8- R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.</p> |
申请人 |
NOVARTIS AG;BRAIN, CHRISTOPHER, THOMAS;CHO, YOUNG SHIN;GIRALDES, JOHN, WILLIAM;LAGU, BHARAT;LEVELL, JULIAN;LUZZIO, MICHAEL;PEREZ, LAWRENCE, BLAS;WANG, YAPING;YANG, FAN |
发明人 |
BRAIN, CHRISTOPHER, THOMAS;CHO, YOUNG SHIN;GIRALDES, JOHN, WILLIAM;LAGU, BHARAT;LEVELL, JULIAN;LUZZIO, MICHAEL;PEREZ, LAWRENCE, BLAS;WANG, YAPING;YANG, FAN |