METHOD OF PREPARING ZANAMIVIR

摘要

PURPOSE: A method for manufacturing zanamivir which suppresses neuraminidase is provided to simply produce zanamivir of high yield and high purity without crystallization of an intermediate. CONSTITUTION: A method for manufacturing zanamivir comprises: a step of reacting 5-aceteamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid methyl ester monohydrate of chemical formula 2 with formic acid in a reaction solvent under the presence of Lindler catalyst to prepare a compound of chemical formula 3; a step of reacting the compound of chemical formula 3 with pyrazole-1H-carboxamidine monohydrochloride at 70-75°C to prepare zanamivir of chemical formula 1. The reaction solvent is a mixture solvent of methanol and water.