| 摘要 |
<p>Benzylamine derivatives (or dipeptide derivatives) of formula (I) may be inhibitors of plasma kallikrein. R1 - R8 and R10 are H or a substituent (or R4, R5 and their connecting atoms combine to form a 5- or 6-membered azacycloalkyl); R9 is aryl or heteroaryl; the substituents are as further defined in claim 1. The benzylamine derivatives may be useful for the treatment of impaired visual acuity, diabetic retinopathy or diabetic macular oedema. The benzylamine derivative may be (S)-N-(4-aminomethyl-benzyl)-2-[(R)-3-(4-ethoxy-phenyl)-2-propionylamino-propionylamino]-3-phenyl-propionamide, (R)-N-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethyl]-3-(4-ethoxy-phenyl)-2-methanesulfonylamino-propionamide or (2S, 3R)-1-[(R)-3-(4-ethoxy-phenyl)-2-propionylamino-propionyl]-3-phenyl-pyrrolidine-2-carboxylic acid 4-aminomethyl-benzylamide.</p> |
