发明名称 |
VITAMIN D GLYCOSIDES AND SULFATES FOR TREATING DISEASES |
摘要 |
<p>Disclosed are methods of treating vitamin D-sensitive diseases without inducing severe forms of hypercalcemia. The methods comprise administering biologically inert vitamin D prodrugs. The vitamin D prodrugs have a vitamin D-drug moiety and a pro moiety, wherein the pro moiety is selected from the group consisting of a glycone moiety and a sulfate moiety. The vitamin D prodrugs are activated by enzymes at target tissues or cells that cleave the pro moiety from the vitamin D-drug moiety, freeing the vitamin D- moiety from the pro moiety in the vicinity of the target tissues or cells. In some versions, the vitamin D-drug moiety is an active vitamin D drug that has direct therapeutic effects at target sites. In other versions, the vitamin D-drug moiety is an inactive vitamin D drug that regulates the production and/or turnover of an active vitamin D drug and, therefore, abundance of the active vitamin D drug at the target site. The methods of the invention prevent large, acute, systemic increases in the free form of the vitamin D-drug moiety that would otherwise lead to hypercalcemia. The methods can be used to treat hyperproliferative, autoimmune, or infectious diseases throughout the body, including the intestine. Compositions of the vitamin D prodrugs useful in the described methods are also disclosed.</p> |
申请公布号 |
WO2011079249(A3) |
申请公布日期 |
2011.08.18 |
申请号 |
WO2010US61977 |
申请日期 |
2010.12.23 |
申请人 |
GLYCOMYR, INC.;GOFF, JESSE, P.;HORST, RONALD, L. |
发明人 |
GOFF, JESSE, P.;HORST, RONALD, L. |
分类号 |
A61K31/592;A61K31/593;A61K31/7032;A61K31/7034;A61K45/06;A61P31/04;A61P35/00;A61P37/02 |
主分类号 |
A61K31/592 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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