发明名称 |
New Optically Pure Compounds for Improved Therapeutic Efficiency |
摘要 |
The present invention relates to new optically pure compounds displaying an improved anticancer activity compared to previously known complex mixtures of stereoisomers thereof. Such compounds are of formula (I): wherein each X independently represents any amino acid; n is 0 or 1; m is an integer between 0 and 3; k is an integer of at least 3; Psi is a reduced bond of formula replacing the peptide amide bond between Lys and Pro; and wherein Lys residues in pseudopeptide units of said compound of formula (I) are either all in L configuration or all in D configuration. A method for preparing such compounds, and therapeutic uses thereof are also provided. The synthetic method involves the selective reduction of the peptide bond between Lys and Pro in a dipeptide intermediate with borane. The therapeutic uses are against cancer, inflammation and for wound healing.
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申请公布号 |
US2011201559(A1) |
申请公布日期 |
2011.08.18 |
申请号 |
US20080993427 |
申请日期 |
2008.05.22 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);IMMUPHARMA (FRANCE) |
发明人 |
BRIAND JEAN PAUL;GUICHARD GILLES;COURTY JOSE;ZIMMER ROBERT;DEVIN CHANTAL;LANG ANNIE;ZHANG HAIXIANG |
分类号 |
A61K38/10;A61P17/02;A61P29/00;A61P35/00;C07K7/02 |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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