| 摘要 |
<p>The present invention relates to a pulsed-release sildenafil pharmaceutical composition that comprises an immediate-release fraction that contains 5 to 100 ng sildenafil and a controlled-release fraction that contains 25 to 150 mg of sildenafil, wherein the controlled-release fraction is composed of particles that contain (a) a superdisintegrant (b) a coating formed from at least one pH-dependent solubility polymer and at least one pH-independent solubility polymer, and (c) optionally, other pharmaceutical excipients. The composition of the invention has a dissolution profile that is more rapid in alkaline medium than in acid medium, which allows the preparation of enhanced pulsed-release formulations.</p> |
