发明名称 |
PROCESS FOR THE PREPARATION OF 4-BROMOMETHYL-[1,1'-BIPHENYL]-2'-CARBONITRILE |
摘要 |
Process for the preparation of the compounds of the general formula (I) - where in the formula R represents cyano group, - COOR1 or -CONR2R3 group - where R1, R2 and R3 stand for identical or non-identical substituents chosen from the following atom or groups: hydrogen atom, straight or branched C1-7 alkyl group, C3-6 cycloalkyl group; or in one given case a tetrazolyl group substituted with a C1-4 alkyl group or triphenylmethyl group - wherein a compound of the general formula (II) - where the meaning of R is as defined above - is reacted with one of the following reagent pairs as bromine sources: bromate with hydrogen sulfite, or bromate with pyrosulfite, or bromide with percarbonate, or bromide with perborate, in aqueous-organic binary systems, and optionally the resulting compound of the general formula (I) is isolated from the reaction mixture by a method known per se. |
申请公布号 |
WO2011073703(A3) |
申请公布日期 |
2011.08.11 |
申请号 |
WO2010HU00141 |
申请日期 |
2010.12.13 |
申请人 |
SANOFI;HUSZAR, CSABA;ARVAI, GEZA;HEGEDUS, ADRIENN |
发明人 |
HUSZAR, CSABA;ARVAI, GEZA;HEGEDUS, ADRIENN |
分类号 |
C07C253/30;C07C257/04 |
主分类号 |
C07C253/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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