DISRUPTIVE POLYMER MICELLE COMPOSITION

摘要

Provided are: a polymeric micelle composition which can stably include a drug and can properly release the drug; and pharmaceutical compositions prepared using the polymeric micelle composition. The polymeric micelle composition has a structure wherein multiple block copolymers, which each have both a hydrophobic polymer chain segment (12) and a hydrophilic polymer chain segment (11), are radially arranged with the hydrophobic polymer chain segment (12) in the inside and with the hydrophilic polymer chain segment (11) in the outside. The composition contains, as the block copolymers, (A) a block copolymer (10) which has affinity for HDL (20) and (B) a block copolymer which has affinity for a lipoprotein other than HDL. When the block polymer (A) with HDL (20) is liberated from the polymeric micelle, a space is formed to accelerate the release of a drug (50) included in the polymeric micelle. The release rate of the drug (50) from the polymeric micelle can be adjusted by controlling the content ratio between the block polymers (A) and (B).