METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS

摘要

The present invention relates to a method for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine. In this reaction the pyridinium ring of the Zincke salt reacts with the amine which induces ring opening followed by ring closing, whereby the nitrogen of the amine becomes part of the N-substituted pyridinium ring. Preferably the amine is a primary amine. Novel purine-substituted pyridyl compounds, which can e.g. used in the above reaction, are also disclosed.