| 摘要 |
An oral composition for use in the treatment of a respiratory disorder comprises a non-steroidal anti-inflammatory drug (NSAID), preferably ibuprofen, and a pharmaceutically acceptable vehicle comprising at least 30% (w/w) lipid, wherein the lipid may be selected from the group including an oil; a fat; a fatty acid such as oleic acid, stearic acid or palmitic acid; a fatty acid ester; a fatty alcohol; a glyceride; a phospholipid; a glycol ester; a sucrose ester; a wax; a glycerol oleate derivative; a medium chain triglyceride or mixtures thereof. Preferably the oil is linseed oil or olive oil. Preferably, the vehicle comprises between 5 and 20% (w/w) alcohol wherein the alcohol is selected from ethanol, propanol or butanol and may also optionally comprise water. Preferably the respiratory disorders are selected from common cold; sinusitis; tonsillitis; otis media; pharyngitis; laryngitis; pneumonia; respiratory distress syndrome (RDS); acute respiratory distress syndrome (ARDS); acute lung injury (ALI); chronic obstructive pulmonary disorder (COPD); cystic fibrosis; bronchiolitis influenza, bacterial infection or fungal infection.
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