摘要 |
<p>Compounds having phosphonic acid groups or a derivative thereof, corresponding to the general formula (I)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ A-[P(O)(OH) 2 ] p €ƒ€ƒ€ƒ€ƒ€ƒ(I),
or a pharmaceutically acceptable derivative thereof, wherein A means a residue of a linear, branched or cyclic, saturated or unsaturated, hydrocarbon residue with n carbon atoms, whereby said residue may be substituted by hydroxyl and/or carboxyl and optionally further interrupted by one or more oxygen and/or sulphur and/or nitrogen atoms, carrying p phosphonic acid groups, wherein n is a number from 4 to 70, and p is 3, 4, 5 or 6, are especially suitable to treat surfaces of Endosseous implants to be applied to a human or animal bone to improve osseointegration.</p> |
申请人 |
UNIVERSITE DE GENEVE;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) |
发明人 |
DESCOUTS, PIERRE;ARONSSON, BJOERN-OWE;GRAETZEL, MICHAEL;VIORNERY, CARINE;PECHY, PETER |