| 发明名称 |
HPRP4s modifiers of the p53 pathway and methods of use |
| 摘要 |
Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.
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| 申请公布号 |
US7993829(B2) |
申请公布日期 |
2011.08.09 |
| 申请号 |
US20070627831 |
申请日期 |
2007.01.26 |
| 申请人 |
EXELIXIS INC. |
发明人 |
FRIEDMAN LORI;PLOWMAN GREGORY D.;HUNG TAK;FRANCIS-LANG HELEN;LI DANIX;FUNKE ROEL P.;COSTA MICHAEL |
| 分类号 |
C12N15/09;C12Q1/68;A61K31/7052;A61K31/7088;A61K31/7105;A61K38/00;A61K39/395;A61K45/00;A61P9/00;A61P35/00;A61P43/00;C12Q1/02;C12Q1/48;G01N33/15;G01N33/50;G01N33/574;G01N33/68 |
主分类号 |
C12N15/09 |
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