发明名称 |
TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX |
摘要 |
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.
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申请公布号 |
US2011190241(A1) |
申请公布日期 |
2011.08.04 |
申请号 |
US20090988501 |
申请日期 |
2009.05.14 |
申请人 |
EMERT-SEDLAK LORI;KODAMA TOSHIAKI;DAY BILLY W;DAI WEIXIANG;TRIBLE RONALD P;SMITHGALL THOMAS E |
发明人 |
EMERT-SEDLAK LORI;KODAMA TOSHIAKI;DAY BILLY W.;DAI WEIXIANG;TRIBLE RONALD P.;SMITHGALL THOMAS E. |
分类号 |
A61K31/635;A61K31/498;A61K31/519;A61K31/5377;A61P31/18;C07D241/44;C07D405/12;C07D491/048 |
主分类号 |
A61K31/635 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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