发明名称 |
Peptide Stabilizer Compounds and Screening Method |
摘要 |
Peptide stabilizer compounds are provided that in combination with a biologically active peptide, can increase the protease elimination half-time of the biologically active peptide in vivo. The peptide stabilizer compounds are preferably in the form of peptide sequences that confer resistance to proteolysis upon conjugated biologically active peptides. Also provided is a method for the selection of novel proteolysis resistant compounds from in vitro generated libraries, and pharmaceutical compositions comprising the stabilizer compounds identified thereby.
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申请公布号 |
US2011189164(A1) |
申请公布日期 |
2011.08.04 |
申请号 |
US20060908790 |
申请日期 |
2006.03.16 |
申请人 |
ISOGENICA LTD |
发明人 |
WILLIAM ELDRIDGE;KEVIN FITZGERALD;NEIL COOLEY;DUNCAN MCGREGOR |
分类号 |
A61K39/395;A61K38/00;A61K38/54;C07K7/08;C07K14/00;C07K16/00;C12N9/96;C12N15/10;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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