7-(2-SUBSTITUTED-3-AMINO-1-TETRAHYDROPYRROLO[3,4-C]PYRAZOLYL)QUINOLINE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION METHODS AND USES AGAINST BACTERIUM AND TUBERCULOSIS

摘要

7-(2-substituted-3-amino-1-tetrahydropyrrolo[3,4-c]pyrazolyl)quinoline carboxylic acid derivatives, their preparation methods and uses against bacterium and tuberculosis are disclosed. 7-(2-substituted-3-amino-1-tetrahydropyrrolo [3,4-c]pyrazolyl)quinoline carboxylic acid derivatives are compounds shown by formula I, pharmaceutically useful salts, physiologically hydrolysable esters, hydrates or isomers thereof. They have unexpected high antibacterial and antitubercular activities, and compared with antibacterial and antitubercular quinolones medicines which are available on the market, they have superior wide-spectrum antibacterial activities and antitubercular activities. Thus, they have a prospective future in preparing antibacterial medicines or antitubercular medicines.