IMPROVED AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS
摘要
The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipid having the structure below and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
申请公布号
EP2350043(A1)
申请公布日期
2011.08.03
申请号
EP20090819991
申请日期
2009.10.09
申请人
TEKMIRA PHARMACEUTICALS CORPORATION;THE UNIVERSITY OF BRITISH COLUMBIA