| 摘要 |
Gibberellic acid is obtained in an improved metabolic process which comprises cultivating an active strain of Gibberella fujikuroi in a nutrient medium, checking active growth to promote gibberellic acid production and adding mevalonic acid as a precursor to the nutrient medium thereby increasing gibberellic acid production. The mevalonic acid may be in the form of salts and esters derived therefrom, particularly esters of phosphoric acid, or conveniently the delta lactone or the corresponding aldehyde 3,5-dihydroxy-3-methyl-n-valeric aldehyde. Alternatively mevaldic acid and isopentenol may be employed as precursors. The precursors may be added continuously or batchwise. Examples describe the preparation of gibberellic acid using mevalonic acid lactone as precursor. Specification 783,611 is referred to.
|
