Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors

摘要

Disclosed herein are pyrido-, pyrazo-, and pyrimido-pyrimidine compounds of formula (I), wherein the substituents are as defined within the specification. Said compounds are ATP-competitive inhibitors of mammalian target of rapamycin (mTOR) and as such are useful in the treatment of melanoma, papillary thyroid tumours, cholangiocarcinomas, colon cancer, ovarian cancer, lung cancer, leukaemia, lymphoid malignancies, carcinomas and sarcomas in the liver, kidney, bladder, prostate, breast and pancreas, and primary and recurrent solid tumours of the skin, colon, thyroid, lungs and ovaries. Also disclosed are methods for the synthesis of compounds of formula (I) and pharmaceutical compositions comprising said compounds.