2-THIOPHEN-2-YL-OXAZOLE, 2-THIOPHEN-2-YL-THIAZOLE AND 2-THIOPHEN-2-YL-1H-IMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS AND THE USE THEREOF

摘要

2-THIOPHEN-2-YL-OXAZOLE, 2-THIOPHEN-2-YL-THIAZOLE AND 2-THIOPHEN-2-YL-1H-IMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS AND THE USE THEREOFAbstractThe present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of[err]This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.