<p>The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a high binding affinity, and a low dissociation rate, with regard to human CD20. Preferably, the CD20 binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).</p>
申请公布号
AU2004240659(B2)
申请公布日期
2011.07.28
申请号
AU20040240659
申请日期
2004.05.20
申请人
APPLIED MOLECULAR EVOLUTION, INC.
发明人
ALLAN, BARRETT W.;DAVIES, JULIAN;MARQUIS, DAVID M.;ONDEK, BRIAN;WATKINS, JEFFRY D.