REMOVAL OF PATHOLOGICAL ALBUMIN FROM A SUBJECT'S PLASMA

摘要

The present invention provides methods and systems of removing pathological albumin from a subject's plasma. Such methods generally comprise: (1) the addition of an anticoagulating agent to the subject's plasma, where the anti-coagulating agent associates with the pathological albumin to form a cryo-reactive albumin; (2) separating the subject's plasma from the subject's blood to form a plasma solution; (3) cooling the plasma solution to a temperature sufficient to form cryoaggregates and cryogels that comprise cryo- reactive albumins; and (4) filtering the cooled down plasma solution through a plasma fractionation filter membrane. In various embodiments, the methods of the present invention also comprise a step of (5) warming the plasma solution to a temperature higher than about 35?C, where the warming occurs before re-infusion. In various embodiments, the methods of the present invention also comprise a hemodialysis step.