| 摘要 |
A device is disclosed for culturing cells in at least one cell culture well. The device includes one or more interconnecting layers having a pattern therein, the pattern including at least one microfluidic channel, at least one cell culture well having an opening at one end and a side wall, the at least one microfluidic channel in fluid communication with the side wall of the at least one cell culture well, and having a maximum channel width substantially less than a maximum width of the at least one cell culture well. The device includes at least one of a controllable valve and a controllable pump in fluid communication with the microfluidic channel, the valve and pump being configured to selectably restrict fluid transport through the microfluidic channel. In some embodiments, the device includes a removable top layer adapted to cover each of the at least one cell culture well.
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