| 发明名称 |
DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS |
| 摘要 |
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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| 申请公布号 |
US2011178101(A1) |
申请公布日期 |
2011.07.21 |
| 申请号 |
US201113008262 |
申请日期 |
2011.01.18 |
| 申请人 |
FATHEREE PAUL R;MCKINNELL ROBERT MURRAY |
发明人 |
FATHEREE PAUL R.;MCKINNELL ROBERT MURRAY |
| 分类号 |
A61K31/497;A61K31/341;A61K31/381;A61K31/40;A61K31/41;A61K31/427;A61K31/4436;A61K31/4439;A61K31/506;A61P9/04;A61P9/12;C07D207/34;C07D307/68;C07D333/38;C07D401/12;C07D403/14;C07D405/12;C07D409/10;C07D409/12;C07D417/10;C07D417/12 |
主分类号 |
A61K31/497 |
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