发明名称 |
TRANSDERMAL ADMINISTRATION OF HYDROPHILIC DRUGS USING PERMEATION ENHANCER COMPOSITION |
摘要 |
Methods, formulations, and drug delivery systems are provided for enhancing the flux of a transdermally administered hydrophilic drug using a basic permeation enhancer composition. The enhancer composition contains an inorganic hydroxide and a weaker, nitrogenous base, wherein the bases are selected such that a 0.1M aqueous solution of the nitrogenous base has a pH that is about 1.0 to about 6.5 lower than the pH of a 0.1M aqueous solution of the inorganic hydroxide. Additionally, the molar ratio of the nitrogenous base to the inorganic hydroxide in the enhancer composition is in the range of about 0.5n:1 to about 20n:1, where n is the number of hydroxide ions per molecule of the inorganic hydroxide.
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申请公布号 |
US2011178044(A1) |
申请公布日期 |
2011.07.21 |
申请号 |
US201113079267 |
申请日期 |
2011.04.04 |
申请人 |
HSU TSUNG-MIN;JACOBSON ERIC;LUO ERIC C;HICKEY ALAN T J;GRICENKO NICOLE T |
发明人 |
HSU TSUNG-MIN;JACOBSON ERIC;LUO ERIC C.;HICKEY ALAN T.J.;GRICENKO NICOLE T. |
分类号 |
A61K31/663;A61K9/70;A61K31/00;A61K31/196;A61K31/5415;A61K47/02;A61K47/18;A61L15/16;A61P3/00;A61P19/10;A61P25/04;A61P25/28;A61P29/00;A61P31/00;A61P35/00 |
主分类号 |
A61K31/663 |
代理机构 |
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地址 |
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