| 发明名称 |
SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS. |
| 摘要 |
<p>The present invention is concerned with novel substituted bicyclic imidazole derivatives of Formula (I) wherein R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 and Y3 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said novel compound as an active ingredient as well as the use of said compounds as a medicament.</p> |
| 申请公布号 |
MX2011006543(A) |
申请公布日期 |
2011.07.20 |
| 申请号 |
MX20110006543 |
申请日期 |
2009.12.16 |
| 申请人 |
ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. |
发明人 |
GIJSEN, HENRICUS JACOBUS MARIA;VAN BRANDT, SVEN FRANCISCUS ANNA;BISCHOFF, FRANCOIS PAUL;TRABANCO-SUAREZ, ANDRES AVELINO;MACDONALD, GREGOR JAMES;BERTHELOT, DIDIER JEAN-CLAUDE;TRESADERN, GARY JOHN |
| 分类号 |
C07D471/04;A61K31/4188;A61P25/28 |
主分类号 |
C07D471/04 |
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