发明名称 |
A METHOD OF PREPARING AFFINITY LIGANDS |
摘要 |
<p>The present invention is a method of preparing affinity ligands, which method comprises to provide a cyclic scaffold comprising a thiol group, a carbonyl group and an amine group; to derivatise the amine group of said scaffold with an electrophile that carries either a functionality capable of affinity interaction or a functionality capable of a second interaction with a target molecule; and to open up the derivatised scaffold and add an amine that carries either a functionality capable of a second interaction or a functionality capable of affinity interaction with a target molecule. The method provides provide affinity ligands, which are capable of affinity interaction as well as a second kind of interaction.</p> |
申请公布号 |
CA2517752(C) |
申请公布日期 |
2011.07.19 |
申请号 |
CA20042517752 |
申请日期 |
2004.03.05 |
申请人 |
AMERSHAM BIOSCIENCES AB |
发明人 |
MALOISEL, JEAN-LUC;THEVENIN, NICOLAS |
分类号 |
B01D15/08;B01D15/38;B01J20/22;B01J20/286;B01J20/32 |
主分类号 |
B01D15/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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