T CELL CLONOTYPES

摘要

The invention relates to a method for identifying and manufacturing an immunogenic agent or vaccine comprising obtaining a population of T cells; exposing said cells to at least one selected antigen and identifying a good TCR which binds maximally to said antigen and a poor TCR which binds minimally to said antigen; designing or obtaining at least one further improved antigen; exposing said good and poor TCRs to said further antigen and determining the response of said good and said poor TCRs to said antigen; and identifying an antigen as said immunogenic agent or vaccine on the basis that it stimulates a response from said good TCRs but does not stimulate a response from said poor TCRs.