INHIBITION OF UBC9-MEDIATED CANCER CELL INVASION AND METASTASIS

摘要

A method for inhibiting invasion or metastasis of cancer cells that contemplates enhancing the expression of miR-224 in those cells, particularly human breast cancer ceils is disclosed. The production of miR-224 can be enhanced by suppressing the expression of Ubc9 in rhose cancer cells. Expression of Ubc9 can be suppressed by administering to those cancer cells an effective amount of antisense Ubc9 having a sequence complementary to a portion of the coding region or a non-coding region of Ubc9 mRNA and has a length of 10 to about 170 bases.