发明名称 |
Use of Oligonucleotides with Modified Bases as Antiviral Agents |
摘要 |
The present invention relates to the use of oligonucleotides having modified nucleobases to inhibit gene expression and/or replication of viruses in a subject. The modified nucleobases may be mercapto-modified bases or hydroxy-modified nucleobases. It is contemplated that the oligonucleotides further comprise a nuclease complex which enhances anti-viral activity of the oligonucleotides.
|
申请公布号 |
US2011171287(A1) |
申请公布日期 |
2011.07.14 |
申请号 |
US20080741531 |
申请日期 |
2008.11.05 |
申请人 |
BALTIC TECHNOLOGY DEVELPMENT, LTD. |
发明人 |
SAARMA MART;MERITS ANDRES;KARELSON MATI |
分类号 |
A61K9/127;A61K31/7115;A61P31/12;A61P31/14;A61P31/20;C07H21/00;C12N5/07;C12N9/96;C12N15/113;C12Q1/70 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|