DENDRIMER OF TUFTSIN AND INFLUENZA MATRIX PROTEIN,AND USE THEREOF

摘要

The present invention provides a dendrimer or derivative thereof,which comprises extracellular domain of influenza matrix protein 2, linker and TUFTSIN. The formula of the dendrimer is (AAN)8-(Lys)4-(Lys)2-Lys-Thr-Lys-Pro-Arg or (AAN)4-(Lys)2-Lys-Thr-Lys-Pro-Arg, in which preferably the amino acid sequence of AAN is Ser-Leu-Leu-Thr-Glu-Val-Glu-Thr-Pro-Ile-Arg-Asn-Glu-Trp-Gly-Cys-Arg-Cys-Asn-Asp-Ser-Ser-Asp. The dendrimer can be used to detect polyclonal antibodies of influenza matrix protein 2, and to stimulate macrophages so as to activate antigen presenting cells. The present invention further provides a vaccine comprising the dendrimer or derivative thereof for inhibiting influenza virus.