DIAMINOTRIAZOLE USEFUL AS INHIBITOR OF PROTEIN KINASE

摘要

PROBLEM TO BE SOLVED: To provide compounds effective as inhibitors of FLT-3, FMS, c-KIT, PDGFR, JAK, AGC subfamily of protein kinase (such as PKA, PDK, p70S6K-1 and -2, and PKB), CDK, GSK, SRC, ROCK and/or SYK protein kinase, and to provide pharmaceutically acceptable compositions thereof. SOLUTION: There are provided protein kinases of formula I. Pharmaceutical compositions containing the compounds, and use methods of the compositions in various diseases are also provided. In specific embodiments, these compounds are effective as inhibitors of FLT-3, JAK-3, PDK-1 and/or SYK protein kinase. COPYRIGHT: (C)2011,JPO&INPIT