Biomarker for Mitochondrial Toxicity Associated with Phospholipidosis

摘要

The present invention relates to a method for determining a risk of a phospholipidotic compound for inducing mitochondrial toxicity which is associated with drug-induced phospholipidosis, comprising a) measuring the level of PAG in a body fluid, b) comparing the level of determined PAG with the level of PAG of a control wherein an increased level of PAG in comparison with that control is indicative that said compound induces mitochondrial toxicity which is associated with drug-induced phospholipidosis.