发明名称 |
CANCER PLATINUM RESISTANCE DETECTION AND SENSITIZATION METHOD |
摘要 |
The phosphorylation status of the BAD protein is a determinant of ovarian cancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BAD phosphorylation status influences cisplatin sensitivity. BAD phosphorylation represents a biomarker that predicts platinum sensitivity and is a therapeutic target to increase platinum sensitivity. The methods employ phospho-specific antibody against a particular amino acid residue or site. Phospho-specific protein characterization methods include immunohistochemical (IHC), flow cytometric, immunofluorescent, capture-and-detection, or reversed phase assay.
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申请公布号 |
US2011166095(A1) |
申请公布日期 |
2011.07.07 |
申请号 |
US20100975970 |
申请日期 |
2010.12.22 |
申请人 |
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.;UNIVERSITY OF SOUTH FLORIDA |
发明人 |
LANCASTER JOHNATHAN M.;MARCHION DOUGLAS C.;CHEN DUNG-TSA |
分类号 |
A61K31/7064;A61P35/00;C12Q1/02;C40B30/06 |
主分类号 |
A61K31/7064 |
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