发明名称 |
USES OF CHEMICALLY-MODIFIED CHOLINESTERASES FOR DETOXIFICATION OF ORGANOPHOSPHORUS COMPOUNDS |
摘要 |
A circulatory long-lived cholinesterase (ChE) protein, such as acetylcholinesterase (AChE) or butyrylcholinesterase (BChE), which is a ChE protein modified with a non-antigenic polymer. The ChE may be AChE, such as native AChE of mammalian origin or of non-mammalian origin, or recombinant AChE. The recombinant AChE may be mutated at one or more amino-acid residues. The BChE may be native BChE of mammalian origin or of non-mammalian origin.
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申请公布号 |
CA2445841(C) |
申请公布日期 |
2011.06.28 |
申请号 |
CA20022445841 |
申请日期 |
2002.04.25 |
申请人 |
STATE OF ISRAEL PRIME MINISTER'S OFFICE ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH |
发明人 |
COHEN, OFER;KRONMAN, CHANOCH;CHITLARU, THEODOR;VELAN, BARUCH;SHAFFERMAN, AVIGDOR |
分类号 |
C12N9/18;A61K38/46;A61K47/30;A61K47/48;C08G65/329;C12N9/96;C12N11/08 |
主分类号 |
C12N9/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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