RECOMBINANT PLASMID DNA CONTAINING SEQUENCE OF MATURE STAPHYLOKINASE Staphylococcus aureus WITH IDENTIFICATION PEPTIDE OF SIX HISTIDINE RESIDUES, Escherichia coli MZ08 STRAIN AND METHOD OF PRODUCING RECOMBINANT PROTEIN CONTAINING SEQUENCE OF MATURE STAPHYLOKINASE GENE WITH IDENTIFICATION PEPTIDE OF SIX HISTIDINE RESIDUES

摘要

FIELD: medicine. ^ SUBSTANCE: recombinant plasmid DNA coding protein of mature staphylokinase Staphylococcus aureus with identification peptide of six histidine residues is described. The Escherichia coli MZ08 strain - producer of recombinant protein of mature staphylokinase St. aureus with identification peptide of six histidine residues is offered. A method of producing recombinant protein of mature staphylokinase with identification peptide of six histidine residues is presented. ^ EFFECT: invention allows producing protein exhibiting high fibrinolytic activity, with reduced yield of recombinant protein of total. ^ 3 cl, 2 dwg