| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to field of medicine and deals with composition of pharmaceutical composition with anti-tuberculosis action. Essence of method: pharmaceutical composition, made in one of solid medicinal forms, includes therapeutically efficient quantity of activesubstance, as such containing combination of isoniazide, sodium para-aminosalicylate and pyridoxine hydrochloride with the following ratio of active substance ingredients, wt %: sodium para-aminosalicylate - 36.8%-90.41%; isoniazide - 1.08%-3.38%; pyridoxine hydrochloride - 0.007%-3.30%. ^ EFFECT: application of claimed pharmaceutical composition with anti-tuberculosis action will ensure high concentration of active medications in blood serum with longer term of preservation, make it possible to prevent formation of drug resistance of mycobacteria to isoniazide, as well as reduce side effects of isoniazide on central nervous system, which will assist in extension of anti-tuberculosis medications arsenal for therapy of tuberculosis, including drug-resistant form. ^ 4 cl, 3 tbl, 3 ex |
